Here’s an Update About Dense Breasts and BRCA

DB & BRCA
Have you been told you have dense breasts? I have. It is actually normal and a common finding. But the issue is that it is hard to tell anything whenever you get a mammogram. On a mammogram, the dense breast appears to be a solid white area, making it difficult to see through. And while having dense breasts makes the screening difficult, a BRCA gene mutation can make it worst.
Breast density is recognized as a predictive factor of breast cancer risk. Also, women who carry the BRCA gene mutation are at high risk of developing breast cancer. Currently, there is no consensus about effective and safe chemoprevention procedure.
That is why I’m excited to share with you the results of a new study.
The primary aim of this study is to investigate the effect of DIM supplementation on breast density in healthy female BRCA carriers.

Some large evidence that shows 3,3-diindolylmethane (DIM) and dimer of indole-3-carbinol can potentially prevent carcinogenesis and tumor development. Moreover, there are also studies that show how DIM induces cell death and prevents cancer development in animal models. The good news is that these compounds can be found in cruciferous vegetables! Not just that, it can also enhance estrogen metabolism among healthy postmenopausal women.

The study assessed 23 female BRCA carriers and was treated with an oral intake of 100g of DIM per day. They performed an MRI before and after the intervention, and the result shows a significant change in the amount of fibro glandular tissue. The mean estradiol level has decreased as well as the testosterone level. Moreover, there were no safety issues encountered during the study and all the side effects are in grade 1 level.

The study concluded that a 1-year supplementation with DIM at 100mg per day in BRCA carriers can significantly decrease the amount of FGT (fibro glandular tissue) on the MRI. 

I do carry Designs for Health DIM and have used it over the years with patient’s menstruation issues including PMS.

If you want to check out the whole study, you can find it here:  https://doi.org/10.1093/carcin/bgaa050

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