Some large evidence that shows 3,3-diindolylmethane (DIM) and dimer of indole-3-carbinol can potentially prevent carcinogenesis and tumor development. Moreover, there are also studies that show how DIM induces cell death and prevents cancer development in animal models. The good news is that these compounds can be found in cruciferous vegetables! Not just that, it can also enhance estrogen metabolism among healthy postmenopausal women.
The study assessed 23 female BRCA carriers and was treated with an oral intake of 100g of DIM per day. They performed an MRI before and after the intervention, and the result shows a significant change in the amount of fibro glandular tissue. The mean estradiol level has decreased as well as the testosterone level. Moreover, there were no safety issues encountered during the study and all the side effects are in grade 1 level.
I do carry Designs for Health DIM and have used it over the years with patient’s menstruation issues including PMS.
If you want to check out the whole study, you can find it here: https://doi.org/10.1093/carcin/bgaa050