Statins – The Anti-Inflammatory Connection

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Statins - The Anti-Inflammatory Connection

Statins – The Anti-Inflammatory Connection

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMPStatin medications have been hauled the king of lowering total and LDL cholesterol.

The position of many in the medical arena support that lowering cholesterol will save us from a deadly cardiovascular incident.

Although I won’t deny that statins in fact are well substantiated to decrease the incidence of cardiovascular mortality the question we all must ask is how do statins reduce this risk?

Is it by reducing cholesterol?  Or is there another mechanism that has been under-rated and in fact may be the “real” benefit of statins and the reduction of cardiovascular disease.

Before I take you are this new journey of statins let’s take a look at some of the cons of consistent statin usage.

It is well documented that statins deplete the body of the powerful anti-oxidant, Co-Enzyme Q10 (CoQ10). CoQ10 plays a vital role in proper functioning of mitochondria.

Here is what we all need to know. Mitochondria are cellular powerhouses and are extremely dense in the heart and other muscles. Here is the big surprise. The health of the mitochondria plays a critical role in insulin sensitivity

So can it possibly mean that by damaging the mitochondria, statins can lead to insulin resistance? It appears so!

So here is what we now know. Statin medications deplete the all-important Co-Enzyme Q10 leading to mitochondria dysfunction. This in turn may in fact lead to heart failure and diabetes. 

A review of my article on insulin resistance is a good review of the real villain in cardiovascular disease.

So with all of the above stated let’s explore the possible real reason statins have been well supported to reduce cardiovascular mortality.

Is it by lowering LDL? Please read my detailed article to gain a better perspective of the LDL issue. Click Here

So what is it about statins that make them work so well?

The answer is there anti-inflammatory benefits. It is now well documented that cardiovascular disease is an inflammatory disease. By reducing coronary inflammation and insulin resistance instead of focusing on lowering LDL cholesterol we can surmise that atherosclerosis can be controlled.

We may ask should one ditch the statins? Well, the evidence is mounting in favor of reducing inflammation and insulin resistance. But I am afraid to say that it is unlikely that the majority of the medical establishment will any time soon stop prescribing statins.

The bottom line is statins do indeed reduce cardiovascular mortality by reducing inflammation but remember at the cost of increasing insulin resistance.

At this point you the reader should do everything in your power to reduce and stop insulin resistance thereby really getting to the root cause of cardiovascular disease.

It is important to firmly understand that insulin resistance is one of the major players in inflammation.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096178/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097389/

https://www.frontiersin.org/articles/10.3389/fphys.2019.00532/full

Statins and Insulin Resistance

Statins and Insulin Resistance

https://academic.oup.com/jes/article/4/8/bvaa057/5837624

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016087/

https://pubmed.ncbi.nlm.nih.gov/25655639/

Statin and Anti-Inflammation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394171/

https://www.ahajournals.org/doi/10.1161/01.cir.0000033635.42612.88

https://www.nature.com/articles/nrcardio.2016.185

Cardiovascular Disease and Inflammation

https://www.jci.org/articles/view/96139

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1483173/

 

The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Grisanti and his functional medicine community. Dr. Grisanti encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Visit www.FunctionalMedicineUniversity.com for more information on our training in functional medicine. Look for practitioners who have successfully completed the Functional Medicine University’s Certification Program (CFMP) www.functionalmedicinedoctors.com. This content may be copied in full, with copyright, contact, creation, and information intact, without specific permission, when used only in a not-for-profit format. If any other use is desired, permission in writing from Dr. Grisanti is required

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